In hypertrophic scarderived keratinocytes, CYP24A1 expression is markedly upregulated, promoting the transcription of pro-fibrotic genes
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Bravo-Vzquez LA, Paul S, Coln-Jurado MG et al (2024) Exploring the therapeutic significance of microRNAs and lncRNAs in kidney diseases
To address this issue, recent studies have explored macrophage-targeted nanocarrier systems utilizing surface receptors such as citrate or scavenger receptors, enabling PROTAC accumulation and selective degradation at the inflammatory or tumor sites (230,231)
Pigmented dark circles stem from melanin accumulation in periorbital skin from chronic sun exposure without adequate protection, post-inflammatory hyperpigmentation from rubbing or allergies, genetic predisposition particularly in darker skin types, or hormonal influences affecting melanocyte activity
